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. 2013 Sep 24;7:145. doi: 10.3389/fncir.2013.00145

FIGURE 1.

FIGURE 1

Optokinetic responses are affected by disruption of glucocorticoid signaling. (A) OKR, in saccades per minute, to motion of a constant sine-wave grating at high contrast. Zebrafish (7 dpf) were initially light adapted (pre) and measured at the indicated time points following a 45 min dark period. gr s357 mutants (n = 7; confirmed by genotyping) recovered more slowly from the dark than either WT (+/+; n = 6) or heterozygotes (s357/+; n = 15). Asterisks: significant difference (p < 0.05). Bars: Standard error of the mean (SEM). (B) Contrast sensitivity of OKR. Light-adapted mutants (n = 12) were not different from heterozygotes (n =10) or WT (n =13). Bars: SEM. (C) Changes in OKR strength of WT fish (7 dpf) following pharmacological reduction or elevation of GR activity. Overnight treatment with RU-486 (RU, 10 μM) diminished the number of saccades to a constant stimulus, whereas overnight dexamethasone (Dex, 100 μM) barely increased them. Control treatment was 1% DMSO. Bars: SEM. Asterisk: significant difference (p < 0.001).