Fig. 3.

Kinetics of deactivating currents for wild-type and F167L, R105C, and P558S myotonic hClC-1 channels in high intracellular chloride. The deactivating currents measured at the beginning of test voltage pulse between − 200 and − 60 mV were fit with a double exponential decay function (Eq. (3)). The fit parameters include a fast time constant (A, τ_fast, 10-ms range), a slow time constant (B, τ_slow, 100-ms range), and their respective contribution to total current (C: A_fast, and D: A_slow), plus the contribution of residual steady state current (E).