Fig. 11.
Scheme showing the P450-catalyzed bioactivation of RTV to the isocyanate intermediate and the reaction with GSH to form RTV-GSH conjugate or the further hydrolysis to stable amine metabolite (Jochheim et al., 2002; Chen et al., 2009).
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.