Fig. 7.

Predicted NPA effects on synaptic and extrasynaptic N1/N2A macroscopic responses. (A) Simulations of macroscopic responses to a brief (1-millisecond) pulse of 1 mM Glu (black arrow) (left), simulated traces are normalized to peak and are overlaid for comparison of deactivation time course (right). Red arrow indicates the peak of NMDA receptor response in the presence of 4 mM NPA. (B) Macroscopic responses to a long (5-second) pulse of 1 mM Glu (black line) were simulated with the models in Fig. 4B, and were recorded as whole-cell currents in the absence (black) or presence (red) of 4 mM ambient NPA (right); insets show the same traces normalized to peak for comparison of desensitization time course (left); and normalized to steady-state level for comparison of deactivation time course (right).