TABLE 1.
Training Drug | Cumulative Intake of the Training Drug | Maximal Response Rate Maintained by PRE-084 | Maximal Response Rate Maintained by the Training Drug |
---|---|---|---|
mg/kg | responses/sec at mg/kg per injection | ||
d-Methamphetamine | 64.7 ± 6.75 | 0.184 ± 0.056 at 0.32 | 0.086 ± 0.015 at 0.10 |
163 ± 21.3 | 0.388 ± 0.177 at 0.32 | 0.068 ± 0.011 at 0.10 | |
243 ± 34.0 | 0.339 ± 0.145 at 0.32 | 0.068 ± 0.011 at 0.10 | |
Heroin | 3.73 ± 0.292 | 0.021 ± 0.004 at 1.0 | 0.064 ± 0.012 at 0.01 |
23.7 ± 3.45 | 0.018 ± 0.004 at 3.2 | 0.070 ± 0.012 at 0.01 | |
Ketamine | 367 ± 30.7 | 0.028 ± 0.007 at 0.32 | 0.376 ± 0.100 at 0.32 |
1630 ± 141 | 0.023 ± 0.004 at 0.32 | 0.427 ± 0.120 at 0.32 |