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Significant attenuation of activation of hepatic stellate cells by rolipram treatment. Liver mRNA levels of (A) TGF-β1 and (B) TβRI 2 weeks after BDL surgery with and without rolipram administration. (C) Immunohistochemical staining of livers for α-SMA, original magnification: 20×. (D) Liver α-SMA mRNA expression 2 weeks after BDL surgery. Data represent means ± S.D. (n = 5–8). **P < 0.01; ***P < 0.001.
