Fig. 5.

Supraspinal or systemic TY027 does not induce CPP in rats. Baseline prior to drug administration resulted in animals spending approximately equal time on both sides of the CPP chambers. Twenty-four hours after two and/or five exposures to morphine (MS, red bars), rats demonstrated a significant increase in the total time spent in the putative conditioned chamber after intracerebroventricular (A) and intravenous (B) injections. Unlike morphine, TY027 (blue bars) administered either intracerebroventricularly (A) or intravenously (B) did not result in significantly increased total time spent in the putative conditioned chamber 24 hours post two and five exposures of TY027 (n = 8–10/treatment/route). Data represent the mean ± S.E.M. *P ≤ 0.05; **P ≤ 0.001.