Fig. 6.

TY027 does not impair gastrointestinal transit in mice. Gastrointestinal transit was evaluated in mice after intravenous administration of either vehicle, MS, or TY027 by measuring gastric emptying of stomach gavaged ⁵¹Cr into the intestine (A) and calculating the geometric center to determine the distance of propulsion (B). MS (1 mg/kg i.v.; n = 8) significantly slowed emptying and reduced the geometric center compared with vehicle, whereas TY027 (3 mg/kg i.v.; n = 8) did not significantly decrease gastric emptying nor reduce the distance of ⁵¹Cr propulsion. Data represent the mean ± S.E.M. **P ≤ 0.001.