Fig. 7.

Opioid-induced emesis occurs with MS but not TY027. (A and B) MS (0.6 mg/kg i.p.), but not TY027 (3 mg/kg i.p.), induced retching in >90% of ferrets, each with an average of 22 retches per animal. (C and D) In the same animals, a higher percentage (58%) of MS-exposed ferrets experienced more vomiting episodes, whereas of those treated with TY027, only 1 of 12 animals experienced a vomiting episode. All ferrets were exposed to vehicle, MS, and TY027 in a randomized and blinded fashion by the observer. *P ≤ 0.05; **P ≤ 0.01 (n = 12 in all groups).