Skip to main content
. 2013 Oct;347(1):7–19. doi: 10.1124/jpet.113.205245

TABLE 1.

TY027 acts as an NK1 antagonist in vivo: effects on SP-induced flinching

Treatment N Mean Number of Flinches in 5 Min (± S.E.M.)
Sa-10% DMSO-SP 5 37.6 (± 7.9)
Sa-TY02730-SP 6 10.6 (± 3.4)*
NLXb- 10% DMSO-SP 6 26.3 (± 5.5)
NLXb-TY02730-SP 6 8.0 (± 3.0)**
a

S, 0.9% saline (1 ml/kg s.c.) given 25 minutes before SP (10 µl, 1 mM i.t.), 10% DMSO, or TY027 (dose given in subscript = micrograms in 5 μl i.t.) 15 minutes prior to SP.

b

NLX (2 mg/kg s.c.) given 25 minutes before SP (10 µl, 1 mM i.t.), 10% DMSO, or TY027 (dose given in subscript = micrograms in 5 μl i.t.) 15 minutes prior to SP.

*

P ≤ 0.05 and **P ≤ 0.01, determined using one-way ANOVA (FlashCalc) with Newman-Kuels post-hoc analysis.