TABLE 1.
Treatment | N | Mean Number of Flinches in 5 Min (± S.E.M.) |
---|---|---|
Sa-10% DMSO-SP | 5 | 37.6 (± 7.9) |
Sa-TY02730-SP | 6 | 10.6 (± 3.4)* |
NLXb- 10% DMSO-SP | 6 | 26.3 (± 5.5) |
NLXb-TY02730-SP | 6 | 8.0 (± 3.0)** |
S, 0.9% saline (1 ml/kg s.c.) given 25 minutes before SP (10 µl, 1 mM i.t.), 10% DMSO, or TY027 (dose given in subscript = micrograms in 5 μl i.t.) 15 minutes prior to SP.
NLX (2 mg/kg s.c.) given 25 minutes before SP (10 µl, 1 mM i.t.), 10% DMSO, or TY027 (dose given in subscript = micrograms in 5 μl i.t.) 15 minutes prior to SP.
P ≤ 0.05 and **P ≤ 0.01, determined using one-way ANOVA (FlashCalc) with Newman-Kuels post-hoc analysis.