TABLE 2.
NLX does not precipitate withdrawal in TY027-pretreated rats
All rats received twice-daily injections of the treatment for 3 days. On day 4, 30 minutes after the final injection, NLX (3 mg/kg s.c.) was injected to precipitate signs of physical withdrawal. Data represent the mean (± S.E.); n = 6–9/treatment.
| Treatment (Dose) |
Symptom |
||||
|---|---|---|---|---|---|
| Teeth Chattering |
Grooming Bouts |
Wet-Dog Shakes |
Weight Loss |
Diarrhea |
|
| g | N/Ntotal | ||||
| Saline | 0.00 (0.00) | 5.00 (1.26) | 0.00 (0.00) | 0.33 (0.49) | 0/6 |
| MS (3 mg/kg) | 24.33 (9.33)* | 4.22 (1.75) | 1.11 (0.39)* | 3.79 (0.32)** | 8/9 |
| DTS | 0.14 (0.14) | 4.71 (1.48) | 0.14 (0.14) | 2.86 (0.63) | 1/7 |
| TY027 (10 mg/kg) | 0.11 (0.11)‡ | 2.89 (0.79) | 0.00 (0.00)‡ | 1.89 (0.45)‡ | 0/9 |
*
P ≤ 0.05; **P ≤ 0.01 compared with vehicle; ‡P ≤ 0.05 compared with MS determined by ANOVA, post-hoc Student-Newman-Keuls.