Fig. 7.
Increasing concentrations of MK-5046 (A and B) or Bantag-1 (C and D) alter the maximal [3H]IP generation stimulated by peptide #1 (1 μM) (A and B) or by supramaximal MK-5046 (1 μM) (C and D) in hBRS-3 Balb 3T3 and NCI-417 cells. The experimental conditions were described under Materials and Methods. The results are the mean ± S.E.M. of at least four experiments, and in each experiment the data points were determined in duplicate. (A and B) Results expressed as the percentage of stimulation caused by a maximal effective concentration of peptide #1 (1 μM) alone. (C and D) Results expressed as a percentage of the stimulation caused by a supramaximal effective concentration of MK-5046 (1 μM) alone. *P < 0.05 versus 1 μM MK-5046 alone.