FIG. 4.

Sirt3 deletion induces a substrate switch and derangement of metabolites in skeletal muscle. Quadriceps muscles from fed male WT and Sirt3 KO mice were collected and subjected to metabolomic analysis as described in research design and methods. Relative levels of organic acids and Kreb cycle intermediates are shown in A, levels of acylcarnitines in B, and amino acid levels in C (n = 4–5; *P < 0.05, Student t test). Asx, asparagine and aspartic acid; Cit, citrulline; Glx, glutamine and glutamic acid; Orn, ornithine.