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. 2013 Sep 17;62(10):3448–3458. doi: 10.2337/db13-0052

FIG. 4.

FIG. 4.

Akita mice with β-cell–specific transgenic overexpression of IRS-2 (βIRS-2-Tg;Akita) were resistant to ER stress–induced apoptosis. A: Body weight gain (n = 10–14). B: Fed blood glucose levels (n = 10–14). *P < 0.05 vs. Akita mice. C and D: Glucose tolerance test (aged 4 weeks, n = 7–9). C: Plasma glucose levels. *P < 0.05 vs. Akita mice. D: Serum insulin levels. E: β-Cell mass (n = 7). The β-cell area is shown as a proportion of the area of the entire pancreas (aged 8 weeks). F: The proportion of TUNEL-positive cells is shown as a percentage of the total number of insulin-positive cells in the pancreas sections (aged 8 weeks, n = 6). G: mRNA expression levels in the islets (aged 8 weeks, n = 6). H and I: Isolated islets of WT or βIRS-2-Tg mice were incubated with 1 μmol/L thapsigargin (Thaps) or vehicle for 24 h at 5.6 mmol/L glucose. H: mRNA expression levels in the islets (n = 6). I: Number of TUNEL-positive β-cells in the islets (at least 30 islets per indicated group). *P < 0.05. n.s., not significant.