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. 2013 Sep 24;7:161. doi: 10.3389/fncel.2013.00161

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Copyright © Persson, Lindberg and Kuhn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aberrant morphology of neuroblastsin the SVZ and RMS after radixin inhibition. Overview (A) and magnification (B) of whole mount preparations of the lateral ventricular wall stained for DCX in control animals showing long and well organized neuroblast chains. (C) The RMS in a coronal section showing the tight association of DCX ⁺ neuroblasts within cellular chains in control animals. Overview (D) and magnification (E) of whole mount preparations of the lateral ventricular wall stained for DCX after DX52-1 infusion showing short and abnormalneuroblasts in aggregations. (F) The RMS in a coronal section showing the disorganized arrangement of DCX⁺ neuroblasts after DX52-1 infusion. Schematic inset in (D) represent the sagittal brain orientation, and in gray the area, of images (A) and (D). Schematic inset in (F) represent the coronal orientation of images (C) and (F). Scale bar in (C) = 50 μm, and (E) = 200 μm.