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. 2013 Sep 24;7:161. doi: 10.3389/fncel.2013.00161

FIGURE 6.

FIGURE 6

Decreased neuroblast proliferation and accumulation of neuroblastsin the posterior RMS after radixin inhibition. (A, B) PSA-NCAM immunoreactivity in the anterior RMS after 4 days of DX52-1 intracerebroventricular infusion of vehicle (A) or DX52-1 (B). (C, D) PSA-NCAM immunoreactivity in the posterior RMS after 4 days of DX52-1 intracerebroventricular infusion of vehicle (C) or DX52-1 (D) shows an accumulation of PSA-NCAM+ neuroblasts in the posterior RMS after radixin inhibition. (E, E′, E″) Example of PHH3 (E) immunoreactive cell expressing PSA-NCAM (E′) and corresponding merged image in (E″). (F) There was no difference in the volume of the anterior RMS of vehicle and DX52-1 treated animals. (I) The volume of the posterior RMS was increased after infusion of DX52-1. (G, J) The number of PHH3 and PSA-NCAM double positive cells in the anterior (G) and posterior (J) RMS was decreased after 4 days of DX52-1 intracerebroventricular infusion. However, there was no difference in the number of PHH3 positive/PSA-NCAM negative cells in the anterior (H) or posterior RMS (K) (*p < 0.05, **p < 0.01). Scale bar in (A) = 50 μm, scale bar in (E″) = 10 μm.