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Results for the average half-life of compounds 3 and 7 with a panel of human recombinant hepatic cytochromes P450.
| Compound | Average T1/2 (min) | ||||||
|---|---|---|---|---|---|---|---|
| CYP1A2 | CYP2C8 | CYP2C9 | CYP2D6 | CYP3A4 | CYP2C19 | CYP2B6 | |
| 3 | 2317 | 62 | 476 | 61 | 33 | 13 | <5 |
| 7 | 1214 | 51 | 230 | 78 | 25 | 18 | <5 |
