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. Author manuscript; available in PMC: 2013 Sep 24.
Published in final edited form as: Neuron Glia Biol. 2008 May;4(2):137–152. doi: 10.1017/S1740925X09990238

Table 2.

PFAM domains in vertebrate myelin proteins

Gene PFAM domain Mouse Chicken Lizard Frog Zebrafish Shark Lamprey
MBP Myelin_MBP 17-170/171 16-173/174 16-169/170 16-175/176 2-95/100 2-155/155
MPZ V-set 29-147/248 29-147/249 6-121/221 26-143/243 21-139/202 27-145/246 22-119/240
MPZ Myelin-P0_C 190-248 190-248 164-222 186-243 176-229/2293 193-246
PLP1 Myelin_PLP 2-277/277 2-277/277 2-277/277 2-280/280 2-245/245 2-246/246 2-108/108
PMP2 Lipocalin 6-132/132 6-132/132 6-132/132 6-132/134 6-132/132 (FABP7) 6-132/134 (FABP3) 5-131/133 (FABP3)
PMP22 PMP22_Claudin 1-153/161 1-153/161 1-154/161 1-152/159 1-150/157 1-152/159 1-157/163
PMP22 L_HGMIC_fpl 6-151 6-148 13/160 13-150 1-148 6-150 9-162
STMN1 Stathmin 4-143/148 4-143/148 4-143/149 4-143/145 6-145/149 6-145/146 8-145/148
*

PFAM domain, in trout IP2 has a very low E-value 0.18.

Legend: The following PFAM domains for MBP (Myelin_MBP, PF01669), MPZ (V-set, PF07686 and Myelin-P0_C, PF01570), PLP1 (Myelin_PLP, PF01275), PMP2 (Lipocalin, PF00061), PMP22 (PMP22_Claudin, PF00822 and L_HGMIC_lpf, PF10242) and Stathmin (PF00836) were examined. Sequences (accession numbers are in supplementary Tables 1A, 1B and 4 online) were used as queries for PFAM sequence analyses (http://pfam.sanger.ac.uk/) and for each gene, included; domain ranges are followed after a slash (/) by the total number of amino acids in the search sequence. Proteins with substantially smaller PFAM domains are in red. Dash (–) indicates absences of PFAM domains.