Table 2.
PFAM domains in vertebrate myelin proteins
| Gene | PFAM domain | Mouse | Chicken | Lizard | Frog | Zebrafish | Shark | Lamprey |
|---|---|---|---|---|---|---|---|---|
| MBP | Myelin_MBP | 17-170/171 | 16-173/174 | 16-169/170 | 16-175/176 | 2-95/100 | 2-155/155 | – |
| MPZ | V-set | 29-147/248 | 29-147/249 | 6-121/221 | 26-143/243 | 21-139/202 | 27-145/246 | 22-119/240 |
| MPZ | Myelin-P0_C | 190-248 | 190-248 | 164-222 | 186-243 | 176-229/2293 | 193-246 | – |
| PLP1 | Myelin_PLP | 2-277/277 | 2-277/277 | 2-277/277 | 2-280/280 | 2-245/245 | 2-246/246 | 2-108/108 |
| PMP2 | Lipocalin | 6-132/132 | 6-132/132 | 6-132/132 | 6-132/134 | 6-132/132 (FABP7) | 6-132/134 (FABP3) | 5-131/133 (FABP3) |
| PMP22 | PMP22_Claudin | 1-153/161 | 1-153/161 | 1-154/161 | 1-152/159 | 1-150/157 | 1-152/159 | 1-157/163 |
| PMP22 | L_HGMIC_fpl | 6-151 | 6-148 | 13/160 | 13-150 | 1-148 | 6-150 | 9-162 |
| STMN1 | Stathmin | 4-143/148 | 4-143/148 | 4-143/149 | 4-143/145 | 6-145/149 | 6-145/146 | 8-145/148 |
PFAM domain, in trout IP2 has a very low E-value 0.18.
Legend: The following PFAM domains for MBP (Myelin_MBP, PF01669), MPZ (V-set, PF07686 and Myelin-P0_C, PF01570), PLP1 (Myelin_PLP, PF01275), PMP2 (Lipocalin, PF00061), PMP22 (PMP22_Claudin, PF00822 and L_HGMIC_lpf, PF10242) and Stathmin (PF00836) were examined. Sequences (accession numbers are in supplementary Tables 1A, 1B and 4 online) were used as queries for PFAM sequence analyses (http://pfam.sanger.ac.uk/) and for each gene, included; domain ranges are followed after a slash (/) by the total number of amino acids in the search sequence. Proteins with substantially smaller PFAM domains are in red. Dash (–) indicates absences of PFAM domains.