Table 2.
Summary of the T-cell responses measured by proliferation and ex vivo IFN-γ cytokine productiona)
| Patients | Early proliferation | Late proliferation | Early ELISpot | Late ELISpot |
|---|---|---|---|---|
| Group 1: failed to clear virus after Rx | ||||
| 1A | + | + | + | + |
| 1B | − | + | − | + |
| 1C | − | + | + | + |
| 1Db) | − | − | − | − |
| 1E | − | + | − | − |
| 1F | − | − | + | + |
| 1Gc) | + | − | − | − |
| 1Hb) | − | − | − | − |
| 1Ib) | − | − | − | − |
| Group 2: successful treatment outcome — absent or transient CD4+ T-cell antiviral responses | ||||
| 2A | − | − | − | − |
| 2B | − | − | − | − |
| 2C | − | − | − | − |
| 2D | − | − | − | − |
| 2E | − | − | − | − |
| 2F | − | − | − | − |
| 2G | − | − | − | − |
| 2H | − | − | + | − |
| 2I | + | − | + | nt |
| 2J | + | − | − | − |
| 2K | − | − | + | + |
| 2L | + | − | + | + |
| 2M | + | + | − | − |
| 2N | + | − | − | − |
| 2O | + | − | − | − |
| 2P | + | − | − | + |
| 2Q | + | − | − | − |
| Group 3: successful treatment outcome — persistent/robust CD4+ T-cell antiviral responses | ||||
| 3A | +++ | +++ | + | − |
| 3B | +++ | +++ | − | − |
| 3C | +++ | +++ | + | + |
| 3D | +++ | + | − | − |
| 3E | +++ | − | ++ | + |
| 3F | +++ | − | − | − |
| 3G | − | − | +++ | +++ |
Responses were divided into early (measured at five time points during the first 28 days) or late (measured 4/5 time points for up to 15 months). A subject was considered to demonstrate an early antiviral immune response if assays were positive at any two time points in the first 28 days; a late antiviral response if assays were positive at any two time points after 28 days. For proliferation assays, a positive response to a protein included at least one result >1000 cpm; for an ELISpot assay, a positive response to a protein included at least one result >10 spot forming cells/106 PBMCs.
Stopped after 3 months.
Stopped after 5 months.
nt: not tested.
+: Transient response to protein (two time points only).
++: Response to one protein at several (>2) time points.
+++: Response to multiple proteins at multiple time points.
−: no response.