Table 1.

Values and coded units of 2^11–6 fractional factorial design for the preparation of 3,5,3′-triiodothyroacetic acid-loaded nanoparticles by the nanoprecipitation method

Exp	A	B	C	D	E	ABCDE = F	ABCD = G	ABCE = H	ABDE = I	ACE = J	BCDE = K
1	−1	−1	−1	−1	−1	−1	1	1	1	1	1
2	1	−1	−1	−1	−1	1	−1	−1	−1	−1	1
3	−1	1	−1	−1	−1	1	−1	−1	−1	1	−1
4	1	1	−1	−1	−1	−1	1	1	1	−1	−1
5	−1	−1	1	−1	−1	1	−1	−1	1	−1	−1
6	1	−1	1	−1	−1	−1	1	1	−1	1	−1
7	−1	1	1	−1	−1	−1	1	1	−1	−1	1
8	1	1	1	−1	−1	1	−1	−1	1	1	1
9	−1	−1	−1	1	−1	1	−1	1	−1	−1	−1
10	1	−1	−1	1	−1	−1	1	−1	1	1	−1
11	−1	1	−1	1	−1	−1	1	−1	1	−1	1
12	1	1	−1	1	−1	1	−1	1	−1	1	1
13	−1	−1	1	1	−1	−1	1	−1	−1	1	1
14	1	−1	1	1	−1	1	−1	1	1	−1	1
15	−1	1	1	1	−1	1	−1	1	1	1	−1
16	1	1	1	1	−1	−1	1	−1	−1	−1	−1
17	−1	−1	−1	−1	1	1	1	−1	−1	−1	−1
18	1	−1	−1	−1	1	−1	−1	1	1	1	−1
19	−1	1	−1	−1	1	−1	−1	1	1	−1	1
20	1	1	−1	−1	1	1	1	−1	−1	1	1
21	−1	−1	1	−1	1	−1	−1	1	−1	1	1
22	1	−1	1	−1	1	1	1	−1	1	−1	1
23	−1	1	1	−1	1	1	1	−1	1	1	−1
24	1	1	1	−1	1	−1	−1	1	−1	−1	−1
25	−1	−1	−1	1	1	−1	−1	−1	1	1	1
26	1	−1	−1	1	1	1	1	1	−1	−1	1
27	−1	1	−1	1	1	1	1	1	−1	1	−1
28	1	1	−1	1	1	−1	−1	−1	1	−1	−1
29	−1	−1	1	1	1	1	1	1	1	−1	−1
30	1	−1	1	1	1	−1	−1	−1	−1	1	−1
31	−1	1	1	1	1	−1	−1	−1	−1	−1	1
32	1	1	1	1	1	1	1	1	1	1	1
Low	PCL	300	NO	10	250	82	0*	62.5	62.5	25	65
High	PMMA	700	IO	50	1000	250	750	187.5	187.5	62.5	130

Note:

^*Nanospheres.

Abbreviations: A, kind of polymer; B, velocity of magnetic stirring (rpm); C, kind of oil; D, velocity to transferring the organic phase into aqueous solution (% of the pump capacity); E, quantity of 3,5,3′-triiodothyroacetic acid (μg); exp, experiment; F, quantity of polymer (mg); G, quantity of oil (mg); h, quantity of Span™ 60; I, quantity of Tween® 80; IO, isodecyl oleate; J, quantity of solvent (mL); K, quantity of water (mL); NO, neem oil; PCL, poly(ɛ-caprolactone); PMMA, poly(methyl methacrylate).