Table 3.

Comparison of transplant strategies in indolent NHL and MCL

	Allo	Auto
Graft issues	Tumor free graft	Potential lymphoma contamination; graft purging benefit not yet proven
Mechanism of effect	GVL effect	High dose chemotherapy effect
Toxicity	Acute and chronic GVHD	Lower acute peritransplant morbidity and mortality
Efficacy	Prolonged remission; potential cure	Not generally curative
Graft quality	Healthy donor graft	Damage from prolonged chemotherapy – risk of myelodysplasia
Recipient factors	Limited patient population (age, performance status, comorbidities)	Safer in patients who are older and with comorbidities
Graft collection	Donor availability	Stem cell collection issues in heavily pretreated marrows

Abbreviations: GVL graft versus lymphoma; GVHD, graft-versus-host disease; allo, allogeneic transplant; auto, autologous transplant.