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The organ grading system for the Glucksberg acute graft-versus-host disease classification
| Stage | Skin/maculopapular rash | Liver/bilirubin, μmol/L | Gastrointestine/diarrhea |
|---|---|---|---|
| + | <25% of body surface | 34–50 | >500 mL |
| ++ | 25%–50% of body surface | 51–102 | >100 mL |
| +++ | Generalized erythroderma | 103–255 | >1500 mL |
| ++++ | Generalized erythroderma with bullae formation and desquamation | >255 | Severe abdominal pain with or without ileus |
