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The overall Glucksberg grading system for acute GvHD
| Grade of aGvHD | Degree of organ involvement |
|---|---|
| I | Skin + to ++ |
| II | Skin + to +++ |
| Gut and/or liver + | |
| Mild decrease in clinical performance | |
| III | Skin ++ to +++ |
| Gut and/or liver ++ to +++ | |
| Marked decrease in clinical performance | |
| IV | Skin ++ to ++++ |
| Gut and/or liver ++ to ++++ | |
| extreme decrease in clinical performance |
Abbreviations: GvHD, graft-versus-host disease, aGvHD, acute GvHD.
