Figure 2.

Structural features of the dG binding pocket. a, A view of the junctional core with bound dG. Red and black dashed lines depict putative hydrogen bonds involved in dG binding and tertiary RNA contact formation, respectively. b, Superposition of the ligand binding pockets from the dG (in colors) and guanine¹⁵ (in grey) riboswitch structures showing accommodation of the deoxyribose sugar ring. Red and black dashed lines depict putative hydrogen bonds involved in dG and guanine recognition, respectively. Arrow shows major conformational changes. c, Superposition of the ligand binding pockets from dG (in colors) and hybrid guanine-dG ¹⁷ (in grey) riboswitch structures. Putative hydrogen bonds between the dG ligand and dG riboswitch are depicted in red dashed lines.