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Our EM heterozygosity estimates (red) and MlRho estimates (blue) on the regions of a San individual genome sequenced to 30–45X and randomly downsampled. At higher coverage, both methods converge to an estimate of 7.45 × 10−4. We note that our estimates for 4X and 5X coverage are much more accurate than those of MlRho. Results for <4X coverage were not possible to obtain from MlRho.
