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. 2013 Sep 23;210(10):2105–2117. doi: 10.1084/jem.20130291

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© 2013 Bouchaud et al.

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Figure 6. — Administration of sIL-15Rα inhibits human and murine psoriasiform disease. (A and B) Development of a psoriatic phenotype in symptomless prepsoriatic human skin transplantated onto AGR129 mice is prevented by injection of sIL-15Rα. Shown is representative hematoxylin-eosin staining at low- (left) and and high-power (right) magnification (A), and acanthosis (B, top), and papillomatosis index (B, bottom) of the human skin grafts 6 wk after transplantation onto AGR129 mice receiving either PBS or sIL-15Rα. Bars, 50 µm. Data are representative of four mice per group. (C and D) WT, WT receiving sIL-15Rα, and Il15ra^−/− mice injected with sIL-15Rα were treated for 6 consecutive days with IMQ cream on their right ear. Mice were assessed as in Fig. 1 (B and C). (E) Primary human keratinocytes were stimulated with either PBS, IL-15, IL-15 plus sIL-15Rα, or sIL-15Rα, followed by analysis of IL-1β, IL-6, and TNF by ELISA. (F and G) Epidermal skin cells from WT mice were stimulated with either PBS, IL-15, IL-15 plus sIL-15Rα, or sIL-15Rα, followed by analysis using flow cytometry. Shown are percentages of IL-17–producing CD3⁺ αβ (F) and γδ T cells (G) as mean ± SD. Data are representative of two independent experiments. P-values were determined using one-way ANOVA; *, P < 0.01; **, P < 0.001; ***, P < 0.0001.