Table I.
BRCA2 mutations and outcomes in children with posterior fossa tumors
| ID | Cancer (age, years) | Nucleotide change I | Nucleotide change II | Outcome | Reference |
|---|---|---|---|---|---|
| 1 | Brain Tumor (3) | 7691/insAT | 9900/insA | Not documented | 4 |
| 2 | Posterior fossa tumor- radiologic findings consistent with medulloblastoma or astrocytoma (4.9) |
6174delT | 9435T→A | Dead | 6 |
| 3 | Astrocytoma (2) | 6174delT | 9435T→A | Dead | 6 |
| 4 | Medulloblastoma (4.5) | 6174delT | 886delGT | Not documented | 6 |
| 5 | Medulloblastoma (2.5) | 5301insA | 7690T→C | Not documented | 6 |
| 6 | Medulloblastoma (3.5) | 4150G→T | 9424C→T | Not documented | 6 |
| 7 | Medulloblastoma (2.3) | 886delGT | 8447T→A | Not documented | 5 |
| 8 | Medulloblastoma (4.3) | 886delGT | 8447T→A | Dead | 5 |
| 9 | Medulloblastom (6) | 886delTG | 5873C→A | Dead * relapse of medulloblastoma at 12 y |
7 |
| 10 | Posterior fossa tumor (1) -VATER associated anamolies |
1548del4 | 1548del4 | Dead | 10 |
| 11 | Medulloblastoma (3.1) - VATER associated anomalies |
6174delT | 9424C→T | Not documented | 3 |
| 12 | Medulloblastoma (1.7) | 6174delT | 886delGT | Alive without evidence of disease |
Current report |
| 13 | Medulloblastoma (2) | 3492insT | IVS19+3A→G | Dead | Personal communication |