Figure 1. Contribution of tumor-associated antigen classes to T-cell reactivity in melanoma-infiltrating lymphocytes. (A and B) Pie charts show the classification of 175 previously described melanoma-associated T-cell epitopes (A) and the distribution of 37 T-cell responses against these tumor-associated antigens (TAAs) previously detected among tumor-infiltrating lymphocytes (TILs) (B) into classes. Please note that each response is only counted once in each patient.¹ (C and D) Pie charts as in (A and B), respectively, with cryptic epitopes considered as a standalone class of TAAs.