Table 3.
Association of allele length with age at onset in patients with PD, AD, and ET.
| Association of allele length with age at onset | ||||||
|---|---|---|---|---|---|---|
| PD (n = 911) | AD (n = 279) | ET (n = 152) | ||||
| Regression coefficient (95% CI) | P | Regression coefficient (95% CI) | P | Regression coefficient (95% CI) | P | |
| Genotype | 0.43 | 0.007 | 0.85 | |||
| S/S | 0.00 (reference) | 0.00 (reference) | 0.00 (reference) | |||
| S/I | 0.02 (−1.60, 1.63) | 1.04 (−1.90, 3.98) | −0.15 (−3.85, 3.55) | |||
| I/I | 1.37 (−1.41, 4.16) | 5.50 (0.27, 10.74) | −0.32 (−7.57, 6.93) | |||
| Repeats on larger allele continuous | ||||||
| 0.20 (−0.48, −0.44) | 0.12 | 0.02 (−0.46, 0.50) | 0.93 | −0.47 (−1.20, 0.25) | 0.20 | |
CI, confidence interval; S, short allele (<7 units); I, intermediate allele (≥7 units).
Regression coefficient and corresponding p results from linear regression models adjusted for gender. After Bonferroni adjustment for multiple testing, p ≤ 0.025 were considered statistically significant (2 tests).