Table 4.
Association of allele length with risk of disease in comparison with controls (n = 314) | ||||||
---|---|---|---|---|---|---|
PD (n = 911) | AD (n = 279) | ET (n = 152) | ||||
OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
Genotype | 0.0081 | 0.54 | 0.64 | |||
S/S | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |||
S/I | 1.37 (1.05, 1.79) | 0.83 (0.55, 1.26) | 0.88 (0.57, 1.37) | |||
I/I | 2.03 (1.17, 3.54) | 0.91 (0.40, 2.06) | 1.30 (0.56, 3.04) | |||
Repeats on larger allele continuous | ||||||
1.06 (1.01, 1.10) | 0.001 | 0.99 (0.93, 1.05) | 0.69 | 0.96 (0.89, 1.03) | 0.27 |
OR, odds ratio; CI, confidence interval; S, short allele (<7 units); I, intermediate allele (≥7 units).
Odds ratios and corresponding p-value results from logistic regression models adjusted for age at onset and gender. After Bonferroni adjustment for multiple testing, p ≤ 0.0083 were considered statistically significant (6 tests).