Table 3.

Non-food and drug administration approved/investigational agents and their mechanism

Name	Mechanism of action
Induction
Alemtuzumab	Monoclonal antibody, CD52
Efaluzimab	Humanized antibody, CD11a/LFA-1
Alefacept	Costimulation inhibitor, CD2 LFA3
Maintenance
Prolonged release tacrolimus	Calcineurin inhibitor
Voclosporin, ISA247	Calcineurin inhibitor
Mizoribine	Purine synthesis inhibitors
Sotrastaurin, AEB071	Protein kinase C inhibitor
Tofacitinib, CP-690550	JAK 3 inhibitor
Treatment of antibody medicated rejection
Bortezomib	Proteasome inhibitor
Eculizumab	Monoclonal antibody, C5 complement protein