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. Author manuscript; available in PMC: 2013 Sep 24.
Published in final edited form as: Nat Med. 2012 Nov 11;18(12):1768–1777. doi: 10.1038/nm.2979

Figure 2.

Figure 2

Obesity in adipocyte-specific Arntl knockout (Ad-Arntl−/−) mice. (a) Body weights of adipocyte-specific Arntl knockout mice (aP2-Cre Arntlfx), littermate Arntlfx controls (No Cre Arntlfx), aP2-Cre controls (aP2-Cre), WT littermates of aP2-Cre controls (WT) and WT mice (WT C57BL/6J) (n = 12 per group). (b) Body weights of adipocyte-specific Arntl knockout mice (adiponectin-Cre Arntlfx), littermate Arntlfx controls (No Cre Arntlfx), adiponectin-Cre controls (adiponectin-Cre) and WT littermates of adiponectin-Cre controls (WT Aghouti) fed either regular chow (open symbols) (n = 6) or HFD starting at 6 weeks of age (n = 9). (c) Body composition of 32-week-old Ad-Arntl−/− and control mice fed a regular diet, and 16-week-old Ad-Arntl−/− and control mice fed HFD (n = 5 per group). *P < 0.05 by two-sample parametric t test. (d) Representative H&E stain images of epididymal WAT tissue isolated from 20-week-old weight-matched Ad-Arntl−/− and control mice on regular diet. Scale bars, 100 µm. (e) Adipocyte area size quantification for white adipocytes from epididymal WAT from weight-matched Ad-Arntl−/− and control mice (20-week-old mice fed a regular diet). *P < 0.05 by two-sample parametric t test. (f) Plasma concentrations of leptin, triglycerides and glucose at different time points of circadian time in 20-week-old mice kept under constant darkness with ad libitum access to a regular chow diet (n = 4 for each time point and group). *P < 0.05 by two-sample Mann-Whitney test. All data in the figure are the mean ± s.e.m.