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. Author manuscript; available in PMC: 2013 Sep 24.
Published in final edited form as: Nat Med. 2012 Nov 11;18(12):1768–1777. doi: 10.1038/nm.2979

Figure 3.

Figure 3

Attenuation of the diurnal rhythm in feeding activity and lower energy expenditure in adipocyte-specific Arntl knockout mice (Ad-Arntl−/−). (a–f) Locomotor activity (a,b), O2 consumption rate (vO2) (c,d) and food intake (e,f) monitored over two consecutive 24-h cycles for 20-week-old mice kept in 12-h light, 12-h dark conditions and fed HFD for 1 week. Results are represented as the totals for the light and dark periods in b, d and f (n = 8 per group). *P < 0.05, **P < 0.01 by two-sample Mann-Whitney test. vO2 values are corrected for body weight, and correction for lean body mass produced similar results. All data in the figure are the mean ± s.e.m.