Skip to main content
. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Genes Brain Behav. 2013 Jul 17;12(6):658–665. doi: 10.1111/gbb.12057

Figure 1. MC4R signaling in D1R neurons regulates body weight and food intake.

Figure 1

(a–d) Restoration of MC4Rs specifically in D1R neurons results in a significant reduction in body weight on chow in male (a) and female (c) mice and on high-fat diet in male (b) and female (d) mice. *P < 0.05, **P< 0.01 and ***P< 0.001 compared with MC4R–TB group by two-way ANOVA with Bonferroni’s post hoc analysis.(e and f) Food intake for genotypes above was measured in separate cohorts of mice at 6–7 weeks of age. Restoration of MC4Rs in D1R neurons decreases intake of both chow and high-fat diet in male (e) and female (f) mice compared with MC4R-TB mice. (g) NMR body composition analysis in 8- to 9-week-old male mice. *P< 0.05, **P< 0.01 and ***P< 0.001 compared between the groups by one-way ANOVA with Tukey’s post hoc analysis. Data are presented as mean±SEM.