Table 2. Predictors of risk of virological failure following cART initiation for 1075 patients.
|
UnivariableCoxmodels
|
MultivariableCoxmodel
|
||||||||
| Hazard Ratio |
95% CI
|
P-value * | Hazard Ratio |
95% CI
|
P-value * | ||||
| Duration at cART initiation (months since date of HIV seroconversion) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| ≤3 | 1 | 0.933 | 1 | 0.592 | |||||
| 4-12 | 0.89 | (0.43, | 1.82) | 0.76 | (0.36, | 1.58) | |||
| ≥12 | 0.86 | (0.53, | 1.73) | 0.72 | (0.38, | 1.36) | |||
| CD4 count at cART initiation (ln cells/mm3 increase) | 0.84 | (0.68, | 1.02) | 0.087 | 0.82 | (0.69, | 0.98) | 0.033 | |
| Age at cART initiation (years) | |||||||||
| <36 | 1 | 1 | 0.08 | ||||||
| ≥36 | 0.64 | (0.47, | 0.87) | 0.005 | 0.75 | (0.55, | 1.03) | ||
| Calendar year of cART initiation | |||||||||
| <2000 | 1 | 1 | <0.001 | ||||||
| ≥2000 | 0.29 | (0.21, | 0.39) | <0.001 | 0.32 | (0.22, | 0.47) | ||
| Identification during acute infection | 0.71 | (0.52, | 0.97) | 0.030 | 0.82 | (0.59, | 1.14) | 0.236 | |
| Female | 0.49 | (0.22, | 1.20) | 0.120 | |||||
| Risk group | |||||||||
| Sex between men | 1 | 0.183 | |||||||
| Injecting Drug users | 0.59 | (0.19, | 1.86) | ||||||
|
0.58 | (0.29, | 1.19) | ||||||
| Class of initial cART | |||||||||
| NNRTI | 1 | <0.001 | 1 | 0.639 | |||||
| Unboosted PI | 2.68 | (1.87, | 3.84) | 1.18 | (0.77, | 1.79) | |||
| Boosted PI | 1.02 | (0.62, | 1.68) | 1.43 | (0.76, | 2.69) | |||
| Other | 1.48 | (0.79, | 2.78) | 1.16 | (0.70, | 1.94) | |||
*
P-values for Wald test for continuous and binary variables and Wald test for heterogeneity for categorical variables