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. 2013 Sep 24;8(9):e75543. doi: 10.1371/journal.pone.0075543

Figure 3. Intrathecal injection of LXA4 and 17(R)-RvD1 decrease carrageenan-induced TNF levels in the CSF.

Figure 3

Bar graphs show the levels of cytokines in pg/ml in CSF from rats pretreated with i.t. RvD1 (300 ng) or LXA4 (1 µg) prior to carrageenan injection. (A) The carrageenan-induced increase in TNF levels was significantly reduced in rats pretreated with LXA4 and 17(R)-RvD1 (A). No significant effect of i.t. LXA4 or 17(R)-RvD1 was observed on CSF levels of IL-1β (B), IL-13 (C), IFN-γ (D), IL-4 (E), or KC/GRO (F). Each bar represents the mean ± S.E.M. # and * represent a significant difference at p<0.05 as compared to the i.t. vehicle (veh) treated group before and 2 hours post carrageenan, respectively.