Table 2.
Cost inputs
| Cost inputs | Cost adjusted to 2011 (US$)a | Data source |
|---|---|---|
| Drug costs (wholesale acquisition cost per dose) | ||
| Linezolid IV 600 mg | $107.10 | First DataBank, Inc34 |
| Linezolid oral 600 mg | $89.39 | First DataBank, Inc34 |
| Vancomycin IV 1 g | $5.79 | First DataBank, Inc34 |
| Cefazolin IV 1 g | $2.19 | First DataBank, Inc34 |
| Daptomycin IV 300 mg (500 mg vial used) | $256.29 | First DataBank, Inc34 |
| Injection costs per dose | $7.21 | Tice et al33 |
| Medical costs | ||
| General ward, per day | $1,348.50 | Candrilli and Mauskopf35 |
| ID specialist, inpatient visit | $231.95 | CPT 99253, inpatient consult, 50th percentile, Ingenix36 |
| Physician outpatient visit | $222.40 | CPT 99215, office visit, 50th percentile, Ingenix36 |
| Laboratory tests, vancomycin | $101.06 | CPT 80069 renal function $64.92 + CPT 80202 vancomycin level $36.14, Ingenix36 |
| Laboratory tests, linezolid | $34.34 | CPT 85025 – complete blood count, Ingenix36 |
| OPAT daily cost | $193.67 | Tice et al32 (fee-for-service with medication related costs removed) |
| PICC placement | $656.80 | CPT 36569 for placement $561.58 + CPT 71010 for X-ray $95.22, 50th percentile, Ingenix36 |
| PICC complication cost per patient | $153.81 | |
| • Physician visit | • 17% (Tice et al31) @ CPT 99215, $222.40 (Ingenix36) | |
| • Declotting procedure with CathFlo | • 7% (Tice et al31) @ CPT 36593 $199.66 (Ingenix36) and drug cost $106.33 (First DataBank34) | |
| • Emergency room visit | • 2% (Moureau et al30) @ CPT 99284 $380.40 (Ingenix36) + facility fees of $222.58 | |
| • Rehospitalization | • 1% (Moureau et al30) @ DRG 920 $5,114.60 (2008 Median cost from HCUP adjusted to US$ 2011) | |
| • PICC replacement including chest X-ray | • 5% (Moureau et al30) @ CPT 36584 $532.42 + CPT 71010 $95.22 (Ingenix36) | |
Notes:
a
Drug prices reported as wholesale acquisition costs 2011, all other costs adjusted to 2011 US$.
Abbreviations: IV, intravenous; ID, infectious disease; OPAT, outpatient therapy; PICC, peripherally inserted central catheter; CPT, current procedural terminology; DRG, diagnosis-related group; HCUP, Healthcare Cost and Utilization Project.