Table 1. Rejection and graft loss in pregnant and non-pregnant women with an organ transplant.
| Organ Transplant Subgroup | Pregnant women with an organ transplant | Non-pregnant women with organ transplant | ||||
|---|---|---|---|---|---|---|
| |
N |
Rejection during pregnancy |
Graft loss within 2 y of delivery |
N |
Rejection within 1 y of transplant |
Graft loss within 2 y of transplant |
|
Kidney* |
|
|
|
|
|
|
| CsA |
517 |
1% |
9% |
17,379 |
11% |
11% |
| CsA mod |
241 |
2% |
6% |
|||
| Tacrolimus |
278 |
2% |
6% |
|||
|
Liver |
|
|
|
|
|
|
| CsA |
100 |
11% |
8% |
2,891 |
19% |
23% |
| CsA modified |
64 |
2% |
3% |
|||
| Tacrolimus |
140 |
5% |
5% |
|||
|
Pancreas-Kidney |
|
|
|
|
|
|
| CsA |
23 |
14% |
13% |
1,855 |
10% |
12% |
| CsA modified |
23 |
0% |
17% |
|||
| Tacrolimus |
42 |
5% |
10% |
|||
|
Heart |
|
|
|
|
|
|
| CsA |
43 |
21% |
0% |
1,259 |
31% |
21% |
| CsA modified |
25 |
4% |
4% |
|||
| Tacrolimus |
35 |
3% |
3% |
|||
| Lung | 31 | 16% | 14% | 1,257 | 32% | 28% |
n = number of pregnancies or number of non-pregnant women. Data was obtained from the NTPR (2011 Annual Report)18 and the Organ Procurement and Transplantation Network on May 24, 2013. The non-pregnant women were 18–39 y old and received their transplant between 2000–2010. CsA: Sandimmune® brand cyclosporine A; CsA modified: newer formulation of CsA became available in 1994 with improved absorption over CsA. *The NTPR data on rejection in kidney transplants during pregnancy is acute, biopsy-proven rejection. Rejection for other organ transplants represents both acute and chronic rejection and is not always biopsy-proven.