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Protein expression of p-AKT/AKT and p-MEK1/2 was decreased following the administration of rosiglitazone (ROZ) and pcDNA3.1-Angptl4-eGFP transfection (***P<0.01). We deduced that the overexpression of angiopoietin-like 4 (Angptl4) protects pulmonary microvascular endothelial cells (RPMVECs) by inhibiting the MEK-Raf-MAPK cascade, thus inhibiting inflammation.
