Table 2.
TERT promoter mutations in thyroid tumors
| Samples | Mutation C228T (n/N (%)) | Mutation C250T (n/N (%)) | Collective mutations (n/N (%)) |
|---|---|---|---|
| Thyroid cancer cell lines | |||
| PTC | 3/3 (100.0) | 0/3 (0.0) | 3/3 (100.0) |
| FTC | 1/2 (50.0) | 0/2 (0.0) | 1/2 (50.0) |
| ATC | 4/7 (57.1) | 3/7 (42.9) | 7/7 (100.0) |
| All | 8/12 (66.7) | 3/12 (25.0) | 11/12 (91.7) |
| Thyroid tumors | |||
| Benign tumor | 0/85 (0.0) | 0/85 (0.0) | 0/85 (0.0) |
| PTC | |||
| CPTC | 23/187 (12.3) | 0/187 (0.0) | 23/187 (12.3) |
| FVPTC | 2/56 (3.6) | 0/56 (0.0) | 2/56 (3.6) |
| TCPTC | 4/13 (30.8) | 0/13 (0.0) | 4/13 (30.8) |
| Columnar | 1/1 (100.0) | 0/1 (0.0) | 1/1 (100.0) |
| All | 30/257 (11.7) | 0/257 (0.0) | 30/257 (11.7) |
| FTC | 9/79 (11.4) | 2/79 (2.5) | 11/79 (13.9) |
| DTC | 39/336 (11.6) | 2/336 (0.6) | 41/336 (12.2) |
| PDTC | 3/8 (37.5) | 0/8 (0.0) | 3/8 (37.5) |
| ATC | 23/54 (42.6) | 2/54 (3.7) | 25/54 (46.3) |
| MTC | 0/16 (0.0) | 0/16 (0.0) | 0/16 (0.0) |
PTC, papillary thyroid cancer; CPTC, conventional PTC; FVPTC, follicular variant PTC; TCPTC, tall-cell PTC; FTC, follicular thyroid cancer; DTC, differentiated thyroid cancer (combination of PTC and FTC); PDTC, poorly DTC; ATC, anaplastic thyroid cancer; MTC, medullary thyroid cancer.