Figure 7.

Differential synaptic drive in reciprocal circuits. A, Left, Schematic illustrating the sampled data used for simulations. Rows indicate the neuron (CA or CC) and columns indicate the subcellular variables of spine volume (V) and dendritic distance (D). Right, Simulations of spike probability as a function of fraction of total BLA inputs. Colored sigmoidal fits correspond to the simulation conditions. B, Same as in A but with CC neurons (black trace) scaled to have 50% fewer total BLA inputs relative to CA neurons (green trace). C, Left, Schematic showing activation of BLA inputs (green) onto CA (green) and CC (black) neurons via wide-field illumination (blue). Right, Synaptic responses and APs evoked by BLA inputs onto sequentially recorded CA and CC neurons. Arrows denote LED stimulation. D, Same as C but for cmPFC inputs (black). E, Ratio of spike probability at CC and CA neurons evoked by BLA (green) or cmPFC (black) inputs. Asterisks indicate significance. Orange dotted line indicates a CC/CA ratio of unity.