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AAV2-BDNF gene delivery does not reduce amyloid plaque formation. A, Amyloid plaques in the CA3 region of APP-GFP mice detected with 4G8 antibody. B, Quantification reveals an absence of plaques in the brain of WT mice and significant increases in the hippocampus of both APP-GFP and APP-BDNF mice. *p < 0.001. Scale bar, 100 μm.
