Table 1.

Neuronal number in medial entorhinal cortex: stereology^a

Age	Layer	WT	APP	APP-BDNF
2–3 mo	Total (layer II-VI)	139,100 ± 3310	128,455 ± 5560 (−7.6%)*	—
7.5 mo	Total (layer II-VI)	130,365 ± 10,814	109,092 ± 6529 (−16.3%)*,**	123,187 ± 9814 (−5.5%)
7.5 mo	Layer II	32,057 ± 3462	25,109 ± 3523 (−21.9%)*,**	28,543 ± 2846 (−11.1%)
7.5 mo	Layer III	46,096 ± 4654	38,469 ± 4833 (−16.5%)*,**	44,524 ± 5289 (−3.4%)
7.5 mo	Layer V-VI	52,211 ± 5599	45,604 ± 3856 (−12.7%)*,**	50,119 ± 4999 (−4.0%)

^aData are mean ± SD.

*p < 0.05, APP versus WT.

**p < 0.05, APP versus APP-BDNF.