Figure 6.

The CSPG receptor LAR differentiates invasive from noninvasive lesions. Representative fluorescence micrographs of (A) noninvasive and (B) invasive lesions highlight the disparity in the expression of the CS-GAG-binding, LAR phosphatase receptor. C, Whereas LAR is uniformly expressed throughout the noninvasive tumor, (D) it is entirely absent from diffusely invasive lesions (n = 6/group). Scale bar, 50 μm. E, Western analysis confirms the dichotomy in LAR expression between invasive and noninvasive tumors.