Table 2.
Effects of TNF inhibitors on the synovial histopathology in RA
| Control group n = 12 |
TNF inhibitors n = 12 |
|
|---|---|---|
| Changes in surface synovial cells | ||
| Pyknosis | 9 | 6 |
| Hydropic degeneration | 5 | 11* |
| Vacuolation | 4 | 11* |
| Degeneration in the sublining layers, including formation of giant cells | 4 | 12* |
| Discoid fibrosis in the sublining layers | 2 | 11* |
| Loss, narrowing or obstruction of vasculature in the sublining layer | 2 | 7 |
| Congestion or dilatation of vasculature in the sublining layer | 7 | 2 |
| Extensive scarring | 3 | 2 |
| Osteoclast | 1 | 3 |
* P < 0.05 by Fisher’s exact test