Fig. 4.

The effect of position in the response of the SEZ to ischaemia. (Panels A, B) Coronal sections of ischaemic rat brains immunostained for GFAP. These images are the ones shown in Fig. 3 with the addition of the sub-division of the SEZ in dorsal and ventral halves (indicated by the arrow; arrowheads indicate the directly affected area of the SEZ). (Panels C, D) Graphs showing the density of mitotic neural stem and progenitor cells within the two halves of the SEZ in sham-operated and ischaemic rats, 4–5 weeks (C) and 1 year (D) after the insult. Densities are shown separately for areas directly affected by ischaemia and for non-affected areas (grey and light grey bars, respectively). [volume = 1 mm (length) × 70 μm (section thickness) × 200 μm (width from the ventricular wall) = 0.014 mm³; * = p < 0.05, compared to the respective normal value (black bars), using two-way ANOVA. Error bars depict SEM. Scale bars: 500 μm].