Table 1.

This table shows different parameters of the cyto-architecture of the homeostatic (measured in sham-operated rats) and the post-ischaemic SEZ. Columns 4 and 5 show the average shortest distance of all mitotic nuclei from the ventricular wall and the nearest blood vessel, respectively. Column 6 shows the number of IB-4 + cells expressed per length of ventricular wall. Note the significant increase in the average distance of mitotic nuclei from the ventricle in the ageing SEZ (15 month old homeostatic niche) and the reversal of this phenotype within the ischaemia-affected domains (15 month old, 1 year post-lesion niche). Also note the decrease in the density of IB-4 + cells in the ageing SEZ (15 month old homeostatic niche). Finally, note the absence of changes in the perivascular distribution of mitotic nuclei (column 5).

Condition	Age	Domain	Distance (μm): ventricle	Distance (μm): blood vessel	IB-4 + cells/length
Homeostasis	4 months (4–5 weeks post-sham operation)	Dorsal	30.9 ± 24.6	14.8 ± 10.2	65.98 ± 12.35
Ventral	28.6 ± 21.4	16.3 ± 11.5	50.92 ± 15.23
15 months (1 year post-sham operation)	Dorsal	53.1 ± 25.7⁎⁎⁎	18.5 ± 10.9	35.60 ± 8.78⁎⁎⁎
Ventral	49.3 ± 20.6⁎⁎⁎	17.3 ± 9.1	28.23 ± 9.64⁎⁎⁎
Post-ischaemic	4 months (4–5 weeks post-lesion)	Dorsal in the lesion	22.5 ± 20.6	17.1 ± 9.6	38.27 ± 21.37
Dorsal outside	25.4 ± 22.7	16.6 ± 9.6	46.54 ± 17.77
Ventral in the lesion	27.0 ± 20.1	15.3 ± 8.9	54.29 ± 12.90
Ventral outside	23.6 ± 18.6	18.2 ± 10.1	31.65 ± 19.22
15 months (1 year post-lesion)	Dorsal in the lesion	29.9 ± 22.6†††	22.4 ± 14.1	40.43 ± 13.45
Dorsal outside	51.3 ± 27.1	18.2 ± 11.1	23.61 ± 13.54
Ventral in the lesion	32.8 ± 21.1†††	17.9 ± 10.0	34.21 ± 10.65
Ventral outside	47.9 ± 20.6	19.4 ± 9.9	30.77 ± 9.32

^⁎⁎⁎p < 0.05 using two-way ANOVA and comparing aged and young homeostatic rats.

^†††p < 0.05 using two-way ANOVA and comparing aged homeostatic rats and post-ischaemic rats 1 year after the insult.