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. 2013 Sep 25;7:171. doi: 10.3389/fnins.2013.00171

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Copyright © 2013 Wellman, Clifford and Rodriguez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean group Intracranial Self-Stimulation (ICSS) rate-frequency scores for wild-type (WT: n = 5) and GHR-R null rats (n = 6) as a function of stimulation intensity. WT rats tested at 75 uA and GHR-R null rats tested at 300 uA exhibit overlapping rate-frequency curves. When GHR-R null rats were tested at 75 uA, their rate-frequency curves dropped to 0. Figure reprinted with permission from Addiction Biology (Wellman et al., 2012).