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Main functional groups used to covalently link the peptide moiety (A) and examples of BFCs (B). BAT is a derivative of TETA; CPTA is a derivative of cyclam, and PCBA is a derivative of cyclen (see Table 1). BAT is conjugated to peptide using the linking agent 2IT (2-iminothiolane) which forms a thioether bond between BAT and the peptide. CPTA and PCBA are conjugated to peptide via an amide linkage. Adapted from Rogers et al. (82).
